Exploring VEGF

Angiogenesis is a hallmark of tumor development

Critical questions in the science of VEGF and angiogenesis

1. What is the significance of VEGF (vascular endothelial growth factor) in tumor angiogenesis?

VEGF and angiogenesis image

As demonstrated in preclinical models:
VEGF has been identified as a regulator of tumor angiogenesis.1

2. Why is VEGF essential throughout the tumor life cycle?

VEGF and tumor life cycle image

As demonstrated in preclinical models:
VEGF may play an essential role throughout the tumor cycle by helping tumor vessels establish, grow, and survive.2

3. What are the effects of VEGF inhibition?

VEGF inhibition

References

  1. Hicklin DJ, Ellis LM. J Clin Oncol. 2005;23:1011-1027. PMID: 15585754
  2. Ellis LM, Hicklin DJ. Nat Rev Cancer. 2008;8:579-591. PMID: 18596824