Explore PI3K

Understanding the PI3K pathway

Key components of the PI3K pathway

Key components of the PI3K pathway

Aberrant activation of the phosphatidylinositol 3-kinase (PI3K) pathway results in the survival and proliferation of tumor cells in many human cancers.1-3


  1. Myers AP, Cantley LC. Targeting a common collaborator in cancer development. Sci Transl Med. 2010;2:48ps45. PMID: 20826838
  2. Song L, Xiong H, Li J, et al. Sphingosine kinase-1 enhances resistance to apoptosis through activation of PI3K/Akt/NF-ΚB pathway in human non-small cell lung cancer. Clin Cancer Res. 2011;17:1839-1849. PMID: 21325072
  3. Rodon J, Dienstmann R, Serra V, Tabernero J. Development of PI3K inhibitors: lessons learned from early clinical trials. Nat Rev Clin Oncol. 2013;10:143-153. PMID: 23400000