HER signaling pathways and cancer
Human epidermal growth factor receptor (HER) signaling has been linked to cancer. When HER signaling pathways are activated, growth and spread of cancer cells may result.1 Because of their involvement in tumor biology, HER family receptors represent an ongoing area of cancer research.2
Activated HER signaling pathways
- Ménard S, Tagliabue E, Campiglio M, Pupa SM. Role of HER2 gene overexpression in breast carcinoma. J Cell Physiol. 2000;281:150-162. PMID: 10623878
- Sliwkowski MX. In: Harris JR, Lippman ME, Morrow M, Osborne CK, eds. Diseases of the Breast. 3rd ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2004:415-426.