Explore ROS1

The ROS1 signaling pathway has been associated with cancer development1,2

  • Genetic rearrangements of ROS1 have been identified in various cancer types and widely studied in non-small cell lung cancer (NSCLC)1
  • While ROS1 is expressed in normal healthy cells, it is not normally expressed in the lung1
    • The role of ROS1 in normal development is not fully understood1
  • ROS1 gene rearrangements are the primary drivers of disease in ROS1+ NSCLC1

The ROS1 signaling pathway1-4

The ROS1 signaling pathway The ROS1 signaling pathway


AKT=v-akt murine thymoma viral oncogene homologue; ERK=extracellular signal-regulated kinase; JAK=Janus kinase; MEK=mitogen-activated protein kinase; mTOR=mammalian target of rapamycin; NSCLC=non-small cell lung cancer; PI3K=phosphatidylinositol-4,5-bisphosphate 3-kinase; RAF=rapidly accelerated fibrosarcoma kinase; Ras=rat sarcoma kinase; ROS1=ROS proto-oncogene 1; STAT=signal transducer and activator of transcription.


  1. Davies KD, Doebele RC. Clin Cancer Res. 2013;19(15):4040-4045. PMID: 23719267
  2. Davies KD, Le AT, Theodoro MF. Clin Cancer Res. 2012;18(17):4570-4579. PMID: 22919003
  3. Morgan GJ, He J, Tytarenko R, et al. Leukemia. 2018. PMID: 29654269
  4. Zhu Y, Lin X, Li X, et al. Thorac Cancer. 2018;9(1):159-163. PMID: 28971587