TRK pathway signaling

Watch this video to learn how TRK fusion proteins activate signaling that may lead to uncontrolled growth in multiple tumors.


Fluorescence in situ hybridization (FISH)

Cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence complementarity.

Fusion protein

A protein created by joining different genes that are transcribed and translated as a single unit.


Immunohistochemistry (IHC)

Uses antibodies to detect the target protein on tissue sections.



Tropomyosin receptor kinase. Members of the TRK protein family of receptors, TRKA, TRKB, and TRKC, are encoded by the 3 NTRK genes, NTRK1, NTRK2, and NTRK3, respectively.