NTRK gene fusions

TRK pathway signaling

Watch this video to learn how TRK fusion proteins activate signaling that may lead to uncontrolled growth in multiple tumors.

TRK pathway signaling may drive tumor survival and growth1,2


  • In normal healthy tissue, the TRK pathway plays a role in the development of the central and peripheral nervous systems and pain sensation3
  • In a wide range of cancer types, NTRK gene fusions can occur; leading to genetically altered TRK receptor proteins may drive signaling pathways involved in cell proliferation, survival, invasion, and angiogenesis1,2

The TRK signaling pathway1,2,4-6

TRK signaling pathway TRK signaling pathway


AKT=v-akt murine thymoma viral oncogene homologue; DAG=diacyl-glycerol; ERK=extracellular signal-regulated kinase; MEK=mitogen-activated protein kinase; mTOR=mammalian target of rapamycin; NTRK=neurotrophic tyrosine receptor kinase;
PI3K=phosphatidylinositol-4,5-bisphosphate 3-kinase; PKC=protein kinase C; PLCy=phospholipase C gamma; RAF=rapidly accelerated fibrosarcoma kinase; Ras=rat sarcoma kinase; TRK=tropomyosin receptor kinase.


  1. Amatu A, Sartore-Bianchi A, Siena S. ESMO Open. 2016;1(2):e000023. PMID: 27843590
  2. Vaishnavi A, Le AT, Doebele RC. Cancer Discov. 2015;5(1):25-34. PMID: 25527197
  3. Chong CR, Bahcall M, Capelletti M. Clin Cancer Res. 2017;23(1):204-213. PMID: 27370605
  4. Khotskaya YB, Holla VR, Farago AF, et al. Pharmacol Ther. 2017;173:58-66. PMID: 28174090
  5. de Lartigue J. Oncology Live [serial online]. 2017;18(15). https://www.onclive.com/publications/oncology-live/2017/vol-18-no-15/trk-inhibitors-advance-rapidly-in-tumoragnostic-paradigm. Accessed September 4, 2018.
  6. Robbins HL, Hague A. Front Endocrinol (Lausanne). 2015;6:188. PMID: 26793165