Researching Tumor Targets and Pathways in Cancer

Targeted strategies aim to recognize altered or overexpressed proteins and their associated pathways.1 How cancer cells exploit these signaling pathways is still unknown and remains a core topic in cancer research and an important area of investigation for Genentech.

Many intricate differences exist among tumor types and across patients, and some signaling pathways exhibit the ability to influence an immune response.2 With a focus on combination regimens, Genentech aims to advance a personalized approach, and a more comprehensive understanding of cancer and its complexities.

Through scientific discovery, Genentech is dedicated to advancing the fight against cancer and identifying the next generation of targeted strategies.

  • Gastrointestinal
  • Genitourinary
  • Gynecologic
  • Lung
  • Monoclonal Antibodies
  • T-cell Bispecific Antibodies


  1. Luo J, Solimini NL, Elledge SE. Principles of cancer therapy: oncogene and non-oncogene addiction. Cell. 2009;136:823-837. PMID: 19269363
  2. Hanahan D, Weinberg D. Hallmarks of cancer: the next generation. Cell. 2011;144:646-674. PMID: 21376230