Related Resources for this page:
- Biological Pathways
- Therapeutic Targets
- Pipeline Molecules
- Research Education
- Clinical Trials
- Cancer Biomarkers
- Multiple Myeloma
- Research BRAF
- Glossary
- BRAF in metastatic melanoma
- Identifying BRAF mutations in melanoma
- VEGF and prognosis in multiple myeloma
- Oncogenic BRAF in melanoma subtypes
- Oncogenic BRAF and prognosis
- Oncogenic BRAF in cancer
- Oncogenic BRAF in melanoma development
- VEGF expression in multiple myeloma
- VEGF pathways in multiple myeloma
- Summary
- VEGF in multiple myeloma
- Multiple Myeloma
- Future Directions
- Antibody-Drug conjugates
- A brief history of ADCs
- Current research in ADCs
- Cytotoxic agent
- Emerging therapeutic options
- Emerging therapeutic options
- How are ADCs designed to work?
- VEGF and prognosis in multiple myeloma
- Glossary
- Monoclonal antibody
- Multimedia Resources
- Receptor-Mediated Endocytosis
- Research ADCs
- Stable linker
- Targeting cancers with ADCs
- VEGF expression in multiple myeloma
- VEGF pathways in multiple myeloma
- Summary
- Summary
- VEGF in multiple myeloma
- What are ADCs?
- Apoptosis
- Bispecific Monoclonal Antibodies
- Glycoengineered Antibodies
- Non-Antibody Biologics
- Targeted Small Molecules
- Apoptosis
- Emerging therapeutic options
- Emerging therapeutic options
- Gastric Cancer
- VEGF and prognosis in multiple myeloma
- Glossary
- MAPK Signaling
- Emerging therapeutic options
- PI3K Inhibitor (GDC-0941)
- Other Tumor Types
- PI3K/Akt/mTOR Signaling
- VEGF expression in multiple myeloma
- VEGF pathways in multiple myeloma
- Summary
- Summary
- VEGF in multiple myeloma
- Traditional Monoclonal Antibodies
- Antibody-Drug conjugates
Multiple Myeloma
Disease Information
Genentech BioOncology is dedicated to advancing the science of myeloma therapy through comprehensive research programs and education. Myeloma is a cancer of the plasma cells in bone marrow.1
Myeloma Demographic Statistics
- In 2010, an estimated 20,180 people in the United States were diagnosed with myeloma and about 10,650 died of the disease2
- The lifetime risk of multiple myeloma is 1 in 1591
Myeloma Epidemiology
- Risk factors include age >65 years, male gender, African American ethnicity, exposure to radiation, family history (risk is 4-fold for persons with a first-degree relative who has the disease), obesity, and other plasma cell diseases1
- Some studies suggest that workplace exposure to oil may increase risk1
- The 5-year relative survival rate for multiple myeloma from 1999 to 2005 is 37%, a significant improvement over the 1975 to 1977 rates (P<0.05)2
Myeloma Symptoms
Myeloma is difficult to detect early. Many patients have no symptoms until the disease has reached an advanced stage.1 The most common symptoms include bone pain, especially in spine, hip, and skull; anemia, leukopenia, or thrombocytopenia; hypercalcemia, neurologic symptoms, decreased renal function; and frequent infection.1
Other links to multiple myeloma disease information
These links give a sampling of other sites offering information on multiple myeloma, which you may find useful in your practice.
- National Cancer Institute at National Institutes of Health, Multiple Myeloma/Other Plasma Cell Neoplasms
- ASCO Cancer Portals - Hematologic Cancer
- Cancer Facts & Figures
Unless otherwise indicated, Genentech, Inc. is neither affiliated with nor endorses any of the organizations listed.
References:
- 1.
- American Cancer Society. Multiple myeloma. www.cancer.org/Cancer/MultipleMyeloma/DetailedGuide/multiple-myeloma-what-is-multiple-myeloma. Accessed April 12, 2011.
- 2.
- American Cancer Society. Cancer Facts & Figures 2010. www.cancer.org/acs/groups/content/@epidemiologysurveilance/
documents/document/acspc-026238.pdf. Accessed April 14, 2011.