Targeting VEGF:
A key mediator of angiogenesis

VEGF

The molecular basis of tumor angiogenesis has been of keen interest in the field of cancer research. The vascular endothelial growth factor (VEGF) pathway is well established as one of the key regulators of this process.

— Hicklin and Ellis, J Clin Oncol, 2005¹

Expression of vascular endothelial growth factor has been identified as a predominant mediator of tumor angiogenesis.² This section of ResearchVEGF.com examines the role of VEGF in tumor development, strategies for inhibiting the VEGF pathway, the effects of direct VEGF ligand inhibition and the importance of continued VEGF inhibition. Click on the links below to learn more.

• The 5 critical questions in the science of VEGF and angiogenesis

References:

1.

Hicklin DJ, Ellis LM. J Clin Oncol. 2005;23:1011-1027. PMID: 15585754

2.

Gottesman, M, Fojo T, Bates S. Nature Rev. 2002;2:48-58 PMID: 11902585