Therapeutic Targets

At Genentech BiOncology, we drive cancer research forward by exploring innovative ways to target the biological mechanisms of cancer. We specifically design molecules so they can selectively bind to a therapeutic target that regulates growth, proliferation, and cell survival.

  • Akt

    Discover how Akt plays a central role in cancer cell growth and survival.

  • Bcl-2

    Learn more about how targeting certain prosurvival Bcl-2 family proteins may lead to apoptosis in cancer cells.

  • CD20

    Learn more about targeting CD20, which is highly expressed on malignant Bcells.

  • EGFL7

    Learn more about how tumor angiogenesis may be curtailed by targeting the EGFL7 molecule.

  • HER1 (EGFR)

    Discover more about the role of HER1 in multiple tumor types.

  • HER2

    Discover how HER2 signaling plays a role in multiple tumor types and why overexpression can lead to a more aggressive disease.

  • HER3

    Examine the role of HER3, a key HER family receptor directly involved in the activation of the PI3K pathway.

  • HER4

    Find out whether this HER family member plays a role in cancer development.

  • MEK

    Discover more about how tumor cell proliferation may be prevented by targeting MEK.

  • MET

    Discover how Met signaling can be dysregulated in cancer and how targeting Met may inhibit tumor cell growth and invasion.

  • mTOR

    Find out how the mTOR kinase acts as a signaling nodal point in promoting the growth and survival of cancer cells.

  • PI3K

    Learn more about the biological effects of targeting PI3K in tumor cells.

  • VEGF

    Learn more about how VEGF contributes to multiple aspects of tumor angiogenesis.