Targeting HER1:
Oncogenic overexpression in multiple tumor types

HER1

These findings indicate that there is an important role for aberrant EGFR signaling in the development and progression of various human tumors. In addition, they provide a strong rationale for EGFR-TK as a target molecule for the development of new cancer therapies.

— Herbst RS and Bunn PA Jr, Clin Cancer Res, 2003¹

HER1, also known as the epidermal growth factor receptor (EGFR), drives the development of multiple solid tumor types. This section of ResearchHERPathways.com focuses on HER1/EGFR signaling, how HER1/EGFR is measured, its prognostic value, and its relationship with specific tumor types. Click on the links below to learn more.

• Dysregulation of HER1/EGFR signaling in cancer
• Evaluation of HER1/EGFR expression
• HER1/EGFR as a prognostic factor
• HER1/EGFR effects in lung cancer
• HER1/EGFR effects in pancreatic cancer
• HER1/EGFR as a potential therapeutic target
• Summary
• References

Reference:

1.

Herbst RS, Bunn PA Jr. Clin Cancer Res. 2003;9:5813-5824.