At Genentech BioOncology, we drive cancer research forward by exploring innovative ways to target the biological mechanisms of cancer. We specifically design molecules so they can selectively bind to a therapeutic target that regulates growth, proliferation, and cell survival.
Discover how Akt plays a central role in cancer cell growth and survival.
Learn more about how targeting certain prosurvival Bcl-2 family proteins may lead to apoptosis in cancer cells.
Learn more about targeting CD20, which is highly expressed on malignant B cells.
Learn more about CD22, a cell surface protein that is only expressed on B cells.
Find out about CD79b, a key component of the B-cell receptor, and its role in malignant B-cell signaling.
Learn more about how tumor angiogenesis may be curtailed by targeting the EGFL7 molecule.
Discover more about the role of HER1 in multiple tumor types.
Discover how HER2 signaling plays a role in multiple tumor types and why overexpression can lead to a more aggressive disease.
Examine the role of HER3, a key HER family receptor directly involved in the activation of the PI3K pathway.
Find out whether this HER family member plays a role in cancer development.
Discover more about how tumor cell proliferation may be prevented by targeting MEK.
Discover how MET signaling can be dysregulated in cancer and how targeting MET may inhibit tumor cell growth and invasion.
Find out how the mTOR kinase acts as a signaling nodal point in promoting the growth and survival of cancer cells.
Learn more about the biological effects of targeting PI3K in tumor cells.
Learn more about how VEGF contributes to multiple aspects of tumor angiogenesis.