VEGF and angiogenesis in renal cell carcinoma (RCC)

The link between inactivation or suppression of the von Hippel-Lindau tumor suppressor gene and the overexpression of VEGF as a key step in the pathogenesis of renal cell carcinoma has been well described.

— Dr. Ronald Bukowski, Kidney Cancer J, 2006¹

Advances in the understanding of the pathogenesis and molecular biology of renal cell carcinoma (RCC) have identified angiogenesis as a key factor in the development of the disease. A major component of the angiogenic process in RCC is vascular endothelial growth factor, or VEGF.²

In this section of ResearchVEGF.com, you will find information on the implications of VEGF in RCC, including the unique role of VEGF and angiogenesis in RCC biology, evidence and prevalence of high VEGF-expressing tumors, and the potential role of VEGF as a prognostic factor.

For more information on a specific topic regarding VEGF in RCC, click on the links below.

References:

1.

Bukowski R. Kidney Cancer J. 2006;4:16-18.

2.

Rini BI, Small EJ. J Clin Oncol. 2005;23:1028-1043.