VEGF Role in Pathology of Multiple Myeloma

VEGF plays a central role in the pathology of multiple myeloma, contributing to the survival, proliferation, and diffusion of plasma cells with paracrine and autocrine mechanisms.¹

As part of a complex interplay between bone marrow components and biological functions, VEGF affects more than just a single mechanism or pathway.² Studies have shown that endothelial cells sustain growth in multiple myeloma not only by providing a vascular supply, but also by providing proliferation and survival stimuli for malignant plasma cells.³

VEGF and MVD, both indicators of angiogenesis, are accepted parameters in hematological tumors and are correlated with clinical outcomes.¹

References:

1.

Ria R, Roccaro AM, Merchionne F, et al. Leukemia. 2003;17:1961-1966. PMID: 14513045

2.

Podar K, Anderson KC. Blood. 2005;105:1383-1395. PMID: 15471951

3.

Jakob C, Sterz J, Zavrski I, et al. Eur J Cancer. 2006;42:1581-1590. PMID: 16797965