VEGF and angiogenesis in lung cancer

...high VEGF levels have been correlated with poor prognosis in patients with lung cancer...

— Herbst et al, J Clin Oncol, 2005¹

As observed in tumor malignancy in general, the process of angiogenesis—and, in particular, vascular endothelial growth factor (VEGF)—may play a critical role in tumor growth and metastasis of lung cancer. It has been shown that

• VEGF is significantly associated with increased microvessel density in lung cancer²
• VEGF is expressed in a majority of non-small cell lung cancer (NSCLC) tumors³
• VEGF is expressed at higher levels as lung cancer progresses⁴
• VEGF may be correlated with carcinogens in lung cancer⁵
• VEGF expression has been associated with decreased survival in lung cancer^2,6

In this section of ResearchVEGF.com, you will find information on the prevalence of VEGF expression in lung cancer, the relationship between VEGF expression and disease progression, correlation of VEGF with carcinogens, and VEGF as a prognostic factor in lung cancer.

For more information on a specific topic regarding VEGF and angiogenesis in lung cancer, click on the links below:

References:

1.

Herbst RS, Onn A, Sandler A. J Clin Oncol. 2005;23:3243-3256.

2.

Yuan A, Yu CJ, Chen WJ, et al. Int J Cancer (Pred Oncol). 2000;89:475-483.

3.

Stefanou D, Batistatou A, Arkoumani E, et al. Histol Histopathol. 2004;19:37-42.

4.

Eriksson P, Brattstrom D, Hesselius P, et al. Neoplasma. 2006;53:285-290.

5.

Jarzynka MJ, Guo P, Bar-Joseph I, Hu B, Cheng SY. Int J Oncol. 2006;28:337-344.

6.

Bremnes RM, Camps C, Sirera R. Lung Cancer. 2006;51:143-158.