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VEGF expression in gastric cancer¹

Different levels of VEGF expression in gastric carcinoma (a and b).

Reprinted with permission from Oh SY, Kwon HC, Kim SH, et al. BMC Cancer. 2008;8:123. Figure 1.

As one of the key proangiogenic factors secreted by many solid tumor types,² elevated levels of VEGF have also been found in the majority of gastric adenocarcinomas.³

Expression of VEGF, serum VEGF, and other proangiogenic factors were studied by Oh et al, who examined 114 specimens of gastric cancer obtained from curative gastrectomies. By immunohistochemical analyses, high VEGF expression was seen in 57.9% of specimens, significantly more frequently in specimens from patients ≥60 years of age (P=0.013) and in intestinal type tumors (P=0.014).¹

References:

1.

Oh SY, Kwon HC, Kim SH, et al. BMC Cancer. 2008;8:123.

2.

Suzuki S, Dobashi Y, Hatakeyama Y, et al. BMC Cancer. 2010;10:659.

3.

Fondevila C, Metges JP, Fuster J, et al. Br J Cancer. 2004;90:206-215.