Biooncology R-VEGF

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Full VEGF & angiogenesis

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The role of VEGF in colorectal cancer (CRC)

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VEGF and prognosis in colorectal cancer

Evidence from numerous studies and analyses points to vascular endothelial growth factor (VEGF) and angiogenesis as prognostic factors in colorectal cancer. For information on a particular outcome that has been correlated with VEGF expression, click on the links in the table below.

Outcome	Study Type and Size	Source
Poor survival	Clinical study (N=60) Meta-analysis of 27 studies	Ishigami et al, Br J Cancer, 1998¹ Des Guetz et al, Br J Cancer, 2006²
Increased risk of relapse	Meta-analysis of 27 studies	Des Guetz et al, Br J Cancer, 2006²
Metastasis	Clinical study (N=133) Clinical study (N=60) Clinical study (N=31)	Tanigawa et al, Cancer Res, 1997³ Ishigami et al, Br J Cancer, 1998¹ Kuramochi et al, Clin Cancer Res, 2006⁴
Tumor invasion and lymph node involvement	Clinical study (N=72) Clinical study (N=90)	Ottaiano et al, Clin Cancer Res, 2006⁵ Saad et al, Mod Pathol, 2006⁶

References:

1.: Ishigami SI, Arii S, Furutani M, et al. Br J Cancer. 1998;78:1379-1384.
2.: Des Guetz G, Uzzan B, Nicolas P, et al. Br J Cancer. 2006;94:1823-1832.
3.: Tanigawa N, Amaya H, Matsumura M, et al. Cancer Res.
1997;57:1043-1046.
4.: Kuramochi H, Hayashi K, Uchida K, et al. Clin Cancer Res. 2006;12:29-33.
5.: Ottaiano A, Franco R, Talamanca AA, et al. Clin Cancer Res. 2006;12:2795-2803.
6.: Saad RS, Kordunsky L, Liu YL, Denning KL, Kandil HA, Silverman JF. Mod Pathol. 2006;19:1317-1323.

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