Related Resources for this page:

Video

Full VEGF & angiogenesis

View video now

Slides

The role of VEGF in colorectal cancer (CRC)

View Slides

Links

VEGF and prognosis in colorectal cancer

Evidence from numerous studies and analyses points to vascular endothelial growth factor (VEGF) and angiogenesis as prognostic factors in colorectal cancer. For information on a particular outcome that has been correlated with VEGF expression, click on the links in the table below.

Outcome Study Type and Size Source
Poor survival Clinical study (N=60)

Meta-analysis of 27 studies 		Ishigami et al, Br J Cancer, 19981

Des Guetz et al, Br J Cancer, 20062
Increased risk of relapse Meta-analysis of 27 studies Des Guetz et al, Br J Cancer, 20062
Metastasis Clinical study (N=133)

Clinical study (N=60)

Clinical study (N=31) 		Tanigawa et al, Cancer Res, 19973

Ishigami et al, Br J Cancer, 19981

Kuramochi et al, Clin Cancer Res, 20064
Tumor invasion
and lymph node
involvement 		Clinical study (N=72)

Clinical study (N=90) 		Ottaiano et al, Clin Cancer Res, 20065

Saad et al, Mod Pathol, 20066
References:
1.
Ishigami SI, Arii S, Furutani M, et al. Br J Cancer. 1998;78:1379-1384. PMID: 9823983
2.
Des Guetz G, Uzzan B, Nicolas P, et al. Br J Cancer. 2006;94:1823-1832. PMID: 16773076
3.
Tanigawa N, Amaya H, Matsumura M, et al. Cancer Res.
1997;57:1043-1046. PMID: 9067267
4.
Kuramochi H, Hayashi K, Uchida K, et al. Clin Cancer Res. 2006;12:29-33. PMID: 16397020
5.
Ottaiano A, Franco R, Talamanca AA, et al. Clin Cancer Res. 2006;12:2795-2803. PMID: 16675573
6.
Saad RS, Kordunsky L, Liu YL, Denning KL, Kandil HA, Silverman JF. Mod Pathol. 2006;19:1317-1323. PMID: 16799477