VEGF and angiogenesis in colorectal cancer

In colorectal cancer, VEGF expression correlates with invasiveness, vascular density, metastasis, recurrence, and prognosis.

— Kabbinavar et al, J Clin Oncol, 2003.¹

Vascular endothelial growth factor (VEGF) has been shown to be involved in the growth and development of colorectal cancer. It has been demonstrated that

• VEGF is expressed early in the progression of colorectal cancer²
• VEGF is more highly expressed in tumors than in distant mucosa³
• VEGF is correlated with poor prognosis^4,5
• VEGF may predict poor response to conventional systemic therapy^6,7

While much research has been done to establish the involvement of VEGF in colorectal cancer, additional studies are needed to further clarify the role of VEGF.

In this section of ResearchVEGF.com, you can learn more about research on the role of VEGF and angiogenesis in colorectal cancer, including evidence and prevalence of VEGF expression in the disease, the relationship between VEGF and prognosis, and VEGF as a predictive factor.

For more information on VEGF and angiogenesis in colorectal cancer, click on the links below.

References:

1.

Kabbinavar F, Hurwitz HI, Fehrenbacher L, et al. J Clin Oncol. 2003;21:60-65.

2.

Takahashi Y, Ellis LM, Mai M. Oncol Rep. 2003;10:9-13.

3.

Kuniyasu H, Yasui W, Shinohara H, et al. Am J Pathol. 2000;157:1523-1535.

4.

Des Guetz G, Uzzan B, Nicolas P, et al. Br J Cancer. 2006;94:1823-1832.

5.

Ishigami SI, Arii S, Furutani M, et al. Br J Cancer. 1998;78:1379-1384.

6.

Ogata Y, Matono K, Mizobe T, et al. Oncol Rep. 2006;15:1111-1116.

7.

Zlobec I, Steele R, Compton CC. Cancer. 2005;104:2517-2521.