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VEGF and MVD

MVD, VEGF, and bladder cancer

Angiogenesis is essential in maintaining the metabolic needs of proliferating tumor cells. Levels of vascular endothelial growth factor (VEGF), one of the primary angiogenic factors in bladder cancer, have been linked to levels of microvessel density (MVD) in a number of studies. Wang et al, for example, investigated the correlation between tumor angiogenesis and bladder cancer. High levels of VEGF expression were shown to positively correlate with higher MVD, as well as with occurrence and progression of bladder cancer.¹

Another study by Miyata et al explored the significance of MVD and angiogenesis in nonmetastatic bladder cancer, and postulated that VEGF-A could modulate MVD. The authors concluded that high levels of VEGF-A expression were associated with MVD.²

References:

1.

Wang S, Xia T, Zhang Z, et al. Zhonghua Wai Ke Za Zhi. 2000;38:34-36.

2.

Miyata Y, Kanda S, Ohba K, et al. Clin Cancer Res. 2006;12(3 Pt 1):800-806.