Summary of VEGF and angiogenesis in
bladder cancer

The importance of vascular endothelial growth factor (VEGF) and angiogenesis in bladder cancer development is supported by a considerable, increasing base of clinical study. These studies have found that high VEGF expression is associated with progression in bladder cancer and can be useful as a prognostic marker. They have also ascertained that high levels of VEGF expression indicate poor prognosis, as they correspond with decreased relapse-free and disease-free survival.^1-3

High levels of VEGF expression have also been shown to positively correlate with high microvessel density, a concurrent predictor of occurrence and progression of bladder cancer.^4,5

References:

1.

Crew JP, O'Brien T, Bradburn M, et al. Cancer Res. 1997;57:5281-5285. PMID: 9393750

2.

Yang S, Wu X, Luo C, et al. World J Urol. 2010;28:473-478. PMID: 20593288

3.

Bernardini S, Fauconnet S, Chabannes E, et al. J Urol. 2001;166:1275-1279. PMID: 11547057

4.

Wang S, Xia T, Zhang Z, et al. Zhonghua Wai Ke Za Zhi. 2000;38:34-36. PMID: 11831983

5.

Miyata Y, Kanda S, Ohba K, et al. Clin Cancer Res. 2006;12(3 Pt 1):800-806. PMID: 16467091