Microvessel Density (MVD) and Progression

MVD as a prognosticator

Several studies examining the significance of tumor angiogenesis as a prognosticator have recognized an association between increasing microvessel density (MVD) and deteriorating prognosis.¹ Bochner et al obtained tissue from 164 patients with invasive primary transitional cell carcinoma (TCC) of the bladder. The level of MVD in the specimens significantly predicted disease-free and overall survival in patients (P<0.0001 and P=0.0007, respectively). The authors concluded that tumor angiogenesis, determined by MVD, is an independent prognostic indicator for patients with invasive TCC of the bladder.¹

Reference:

1.

Bochner BH, Cote RJ, Weidner N, et al. J Natl Cancer Inst. 1995;87:1603-1612. PMID: 7563203