Share

 
 

Want information on dosing?

Reimbursement & patient access?

See our Approved Products

Biooncology R-VEGF

Related Resources for this page:

Video

Full VEGF & angiogenesis

View video now

Slides

Science of VEGF and angiogenesis

View Slides

Links

Angiogenesis is essential to tumor development

A hallmark of cancer throughout tumor development

While there are more than 100 distinct types of cancer (and considerable heterogeneity within each tumor type), there exists a remarkable similarity in the pathologic traits that collectively drive tumor growth. Across most—if not all—malignancies, sustained angiogenesis is considered to be one of these central hallmarks of cancer.1

Acquired capabilities of cancer2

Response to systemic therapy based on VEGF status

Reprinted from Hanahan D, Weinberg RA, "The Hallmarks of Cancer: The Next Generation" in Cell, 2011;144:646-674, with permission from Elsevier.

In their seminal review paper, "The Hallmarks of Cancer," and a recent update paper, Hanahan and Weinberg proposed 6 acquired capabilities of cancer cells and gave examples of possible enabling mechanisms.1,2

Angiogenesis is 1 of the 6 cellular transformations that lead to malignant growth

Acquired Capability Possible Cancer-enabling Mechanism
1. Sustaining proliferative signaling Oncogene activation (Activated H-Ras)
2. Resisting cell death Production of survival growth factors, such as IGF
3. Evading growth suppressors Disruption of retinoblastoma protein (pRb) pathway
4. Enabling replicative immortality Gain of telomerase function
5. Inducing angiogenesis Induction of VEGF production
6. Activating invasion and metastases Inactivation of E-cadherin

The establishment of "inducing angiogenesis" as one of the fundamental "hallmarks of cancer" is based on more than a century of research. To learn more about these research milestones, view the History of VEGF research section.

References:
1.
Hanahan D, Weinberg RA. Cell. 2000;100:57-70.
2.
Hanahan D, Weinberg RA. Cell. 2011;144:646-674.