2 Critical questions in the science of VEGF and angiogenesis

  1. Question 1 preview icon - “Why is the VEGF ligand essential throughout tumor development?” Why is the VEGF ligand essential throughout tumor development? arrow
  2. Question 2 preview icon - “Why do tumors progress?” Why do tumors progress? arrow
Why is the VEGF ligand essential throughout tumor development?
The VEGF ligand may play an essential role throughout tumor development by helping tumor vessels establish, grow, and survive1
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Why do tumors progress?
Tumor progression may occur through acquired resistance (with agents that target the tumor directly) or through the activation of secondary pathways (with agents that target VEGF directly)10-12
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  1. Why is the VEGF ligand essential throughout tumor development?

  2. Why do tumors progress?

Ellis LM, Hicklin DJ. Nat Rev Cancer. 2008;8:579-591. PMID: 18596824
Hicklin DJ, Ellis LM. J Clin Oncol. 2005;23:1011-1027. PMID: 15585754
Baka S, Clamp AR, Jayson GC. Expert Opin Ther Targets. 2006;10:867-876. PMID: 17105373
Presta LG, Chen H, O'Connor SJ, et al. Cancer Res. 1997;57:4593-4599. PMID: 9377574
Jain RK, Duda DG, Clark JW, Loeffler JS. Nat Clin Pract Oncol. 2006;3:24-40. PMID: 16407877
Borgström P, Hillan KJ, Sriramarao P, Ferrara N. Cancer Res. 1996;56:4032-4039. PMID: 8752175
Borgström P, Bourdon MA, Hillan KJ, et al. Prostate. 1998;35:1-10. PMID: 9537593
Lee CG, Heijn M, di Tomaso E, et al. Cancer Res. 2000;60:5565-5570. PMID: 11034104
Willett CG, Boucher Y, di Tomaso E, et al. Nat Med. 2004;10:145-147. PMID: 14745444
Yuan F, Chen Y, Dellian M, et al. Proc Natl Acad Sci U S A. 1996;93:14765-14770. PMID: 8962129
Mancuso MR, Davis R, Norberg SM, et al. J Clin Invest. 2006;116:2610-2621. PMID: 17016557
Aita M, Fasola G, Defferrari C, et al. Crit Rev Oncol Hematol. 2008;68:183-196. PMID: 18606548
Sweeney CJ, Miller KD, Sledge GW. Trends Mol Med. 2003;9:24-29. PMID: 12524207
Ton NC, Jayson GC. Curr Pharm Des. 2004;10:51-64. PMID: 14754405
Bergers G, Hanahan D. Nat Rev Cancer. 2008;8:592-603. PMID: 18650835

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