2 Critical questions in the science of VEGF and angiogenesis

  1. Question 1 preview icon - “Why is the VEGF ligand essential throughout tumor development?” Why is the VEGF ligand essential throughout tumor development? arrow
  2. Question 2 preview icon - “Why do tumors progress?” Why do tumors progress? arrow
Why is the VEGF ligand essential throughout tumor development?
The VEGF ligand may play an essential role throughout tumor development by helping tumor vessels establish, grow, and survive1
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Why do tumors progress?
Tumor progression may occur through acquired resistance (with agents that target the tumor directly) or through the activation of secondary pathways (with agents that target VEGF directly)10-12
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  1. Why is the VEGF ligand essential throughout tumor development?

  2. Why do tumors progress?

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Ellis LM, Hicklin DJ. Nat Rev Cancer. 2008;8:579-591. PMID: 18596824
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Hicklin DJ, Ellis LM. J Clin Oncol. 2005;23:1011-1027. PMID: 15585754
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Baka S, Clamp AR, Jayson GC. Expert Opin Ther Targets. 2006;10:867-876. PMID: 17105373
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Presta LG, Chen H, O'Connor SJ, et al. Cancer Res. 1997;57:4593-4599. PMID: 9377574
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Jain RK, Duda DG, Clark JW, Loeffler JS. Nat Clin Pract Oncol. 2006;3:24-40. PMID: 16407877
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Borgström P, Hillan KJ, Sriramarao P, Ferrara N. Cancer Res. 1996;56:4032-4039. PMID: 8752175
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Borgström P, Bourdon MA, Hillan KJ, et al. Prostate. 1998;35:1-10. PMID: 9537593
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Lee CG, Heijn M, di Tomaso E, et al. Cancer Res. 2000;60:5565-5570. PMID: 11034104
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Willett CG, Boucher Y, di Tomaso E, et al. Nat Med. 2004;10:145-147. PMID: 14745444
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Yuan F, Chen Y, Dellian M, et al. Proc Natl Acad Sci U S A. 1996;93:14765-14770. PMID: 8962129
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Mancuso MR, Davis R, Norberg SM, et al. J Clin Invest. 2006;116:2610-2621. PMID: 17016557
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Aita M, Fasola G, Defferrari C, et al. Crit Rev Oncol Hematol. 2008;68:183-196. PMID: 18606548
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Sweeney CJ, Miller KD, Sledge GW. Trends Mol Med. 2003;9:24-29. PMID: 12524207
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Ton NC, Jayson GC. Curr Pharm Des. 2004;10:51-64. PMID: 14754405
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Bergers G, Hanahan D. Nat Rev Cancer. 2008;8:592-603. PMID: 18650835

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