HER Pathways are of critical importance in cancer

Beginning with benign hyperplasia and extending through invasive metastasis, a number of studies demonstrate that [HER family] receptor activation can play a major role in all aspects of cancer development.

— Sliwkowski MX, "Alterations in the ErbB Signaling Network in Breast Cancer"¹

This section of ResearchHERPathways.com introduces the HER receptors and the methods in which they interact. Click on the links below to learn more.

• What are HER receptors?
• What are ligands and how do they relate to receptors?
• How are HER receptors activated?
• What is receptor dimerization? What are downstream signaling effects?
• What tumor types are influenced by HER pathways?
• Can HER pathways be therapeutic targets?
• Summary of HER pathways in cancer