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HER Pathways are of critical importance in cancer
— Sliwkowski MX, "Alterations in the ErbB Signaling Network in Breast Cancer"1
Beginning with benign hyperplasia and extending through invasive metastasis, a number of studies demonstrate that [HER family] receptor activation can play a major role in all aspects of cancer development.
This section of ResearchHERPathways.com introduces the HER receptors and the methods in which they interact. Click on the links below to learn more.
- What are HER receptors?
- What are ligands and how do they relate to receptors?
- How are HER receptors activated?
- What is receptor dimerization? What are downstream signaling effects?
- What tumor types are influenced by HER pathways?
- Can HER pathways be therapeutic targets?
- Summary of HER pathways in cancer