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Summary:HER3 in Cancer
HER3 is a key component of HER2–mediated tumorigenesis
- HER3 is a requirement for HER2 signaling in cancer2
- HER3 enables HER2 signaling by dimerizing with HER2
- Effects of HER2:HER3 signaling include:
- Activation of the PI3K signaling pathway2
- Escape from HER2 inhibition6
HER3 represents a potential therapeutic target
- Methods of targeting could include:
- Targeting HER2:HER3 dimerization22
- Targeting HER3 ligands
- Targeting downstream signaling pathways2
Additional clinical research is needed to better clarify the role of HER3 in cancer.