HER3 Receptor Overview

The central role of HER3 signaling in HER2–amplified breast cancer suggests that HER3 is a promising therapeutic target.

— Lee-Hoeflich ST et al, Cancer Res, 2008¹

HER3 is increasingly coming under investigation for its role in the development of cancer. This section of ResearchHERPathways.com focuses on the way HER3 may cause cancer cells to grow and spread in spite of currently available therapeutic agents, as well as its prognostic value and role in breast and ovarian cancers. Click on the links below to learn more.

• Dysregulation of HER3 signaling in cancer
• Evaluation of HER3 expression
• HER3 effects in ovarian cancer
• HER3 effects in breast cancer
• HER3 as a potential therapeutic target
• Summary
• References