HER2 Receptor Overview

Patients with multiple copies of the [HER2] gene in DNA from their tumors had a shorter time to relapse as well as a shorter overall survival indicating that gene amplification was prognostic for disease behavior in these individuals.

— Slamon D et al, Science, 1989¹

Dysregulation of HER2 signaling drives the development of multiple tumor types. This section of ResearchHERPathways.com explores the biology of HER2, the methods by which it is detected, its value as a prognostic factor, and its role in breast and ovarian cancer. Click on the links below to learn more.

• Dysregulation of HER2 signaling in cancer
• Methods of evaluating HER2 expression
• HER2 as a prognostic factor
• HER2 effects in breast cancer
• HER2 effects in ovarian cancer
• HER2 as a therapeutic target
• Summary of HER pathways in cancer