Research HER
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HER1 EGFR Overexpression and Prognosis
HER1/EGFR overexpression has been correlated with shorter overall survival
In a 2004 study (N=130), Selvaggi et al showed a statistically significant correlation between HER1/EGFR overexpression (defined as expression in more than 10% of examined cells) and shorter overall survival in patients with completely resected stage I-IIIA non-small cell lung cancer (NSCLC).12 The results of other research have suggested that, rather than receptor overexpression, it is the level of receptor phosphorylation that influences prognosis.10 Selvaggi G et al. Epidermal growth factor receptor overexpression correlates with a poor prognosis in completely resected non-small-cell lung cancer. Ann Oncol. 2004;15:28-32. By permission of the European Society for Medical Oncology.
HER1/EGFR in a negative prognostic factor
The relationship between HER1/EGFR and prognosis has been studied in multiple solid tumor types, including NSCLC and pancreatic cancer.
- In NSCLC, the relationship between HER1/EGFR and prognosis is complex, and may relate to receptor activation more than to overexpression10
- In a study of patients with resected stage I-IIIA NSCLC (N=130), overexpression of HER1/EGFR was significantly correlated with shorter overall survival (P<0.001)12
- An additional study by Kanematsu et al (N=36) showed that, in NSCLC, a higher degree of HER1/EGFR phosphorylation, rather than receptor overexpression, significantly correlated with both shorter time to progression and shorter overall survival (P=0.002 for both)10
- This result suggests that increased HER1/EGFR pathway signaling can influence prognosis even in the absence of receptor overexpression10
- In pancreatic cancer, research suggests that HER1/EGFR is a negative prognostic factor
- In a 2004 study by Ueda et al (N=76), HER1/EGFR overexpression was significantly correlated with higher tumor grade (P<0.001)13
Link to abstract on PubMed - An earlier study by Yamanaka et al (N=87) showed that co-expression of HER1/EGFR and at least 1 of its associated ligands was correlated with larger tumor size, more advanced stage of disease, and shorter overall survival14
Link to abstract on PubMed
- In a 2004 study by Ueda et al (N=76), HER1/EGFR overexpression was significantly correlated with higher tumor grade (P<0.001)13