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References on Sonic Hedgehog Pathway :
You can view the abstracts for the references listed below via the National Library of Medicine's PubMed service. Just click the PubMed links. Click here to view the PubMed disclaimer and copyright notice.
- 1.
- Scales SJ, de Sauvage FJ. Mechanisms of hedgehog pathway activation in cancer and implications for therapy. Trends Pharmacol Sci. 2009;30:303-312.
Link to abstract on PubMed - 2.
- Hahn H, Wicking C, Zaphiropoulos PG, et al. Mutations of the human homolog of drosophila patched in the nevoid basal cell carcinoma syndrome. Cell. 1996;85:841-851.
Link to abstract on PubMed - 3.
- Johnson RL, Rothman AL, Xie J, et al. Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science. 1996;272:1668-1671.
Link to abstract on PubMed - 4.
- Gailani MR, Ståhle-Bäckdahl M, Leffell DJ, et al. The role of the human homologue of drosophila patched in sporadic basal cell carcinoma. Nat Genet. 1996;14:78-81.
Link to abstract on PubMed - 5.
- Wolter M, Reifenberger J, Sommer C, Ruzicka T, Reifenberger G. Mutations in the human homologue of the drosophilia segment polarity gene patched (PTCH) in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. Cancer Res. 1997;57:2581-2585.
Link to abstract on PubMed - 6.
- Unden AB, Holmberg E, Lundh-Rozell B, et al. Mutations in the human homologue of drosophila patched (PTCH) in basal cell carcinomas and the Gorlin syndrome: different in vivo mechanisms of PTCH inactivation. Cancer Res. 1996;56:4562-4565.
Link to abstract on PubMed - 7.
- Xie J, Murone M, Luoh S-M, et al. Activating smoothened mutations in sporadic basal-cell carcinoma. Nature. 1998;39:90-92.
Link to abstract on PubMed - 8.
- Reifenberger J, Wolter M, Weber RG, et al. Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system. Cancer Res. 1998;58:1798-1803.
Link to abstract on PubMed - 9.
- Gailani MR, Bale SJ, Leffell DJ, et al. Developmental defects in Gorlin syndrome related to a putative tumor suppressor gene on chromosome 9. Cell. 1992;69:111-117.
Link to abstract on PubMed - 10.
- Gorlin RJ. Nevoid basal cell carcinoma (Gorlin) syndrome. Genet Med. 2004;6:530-539.
Link to abstract on PubMed - 11.
- Pietsch T, Waha A, Koch A, et al. Medulloblastomas of the desmoplastic variant carry mutations of the human homologue of Drosophila patched. Cancer Res. 1997;57:2085-2088.
Link to abstract on PubMed - 12.
- Raffel C, Jenkins RB, Frederick L. Sporadic medulloblastomas contain PTCH mutations. Cancer Res. 1997;57:842-845.
Link to abstract on PubMed - 13.
- Xie J, Johnson RL, Zhang X, et al. Mutations of the PATCHED gene in several types of sporadic extracutaneous tumors. Cancer Res. 1997;57:2369-2372.
Link to abstract on PubMed - 14.
- Rogers HW, Weinstock MA, Harris AR, et al. Incidence estimate of nonmelanoma skin cancer in the United States, 2006. Arch Dermatol. 2010;146:283-287.
Link to abstract on PubMed - 15.
- Von Hoff DD, LoRusso PM, Rudin CM, et al. Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. N Engl J Med. 2009;361:1164-1172.
Link to abstract on PubMed - 16.
- Raszewski RL, Guyuron B. Long-term survival following nodal metastases from basal cell carcinoma. Ann Plast Surg. 1990;24:170-175.
Link to abstract on PubMed - 17.
- Reifenberger J, Wolter M, Knobbe CB, et al. Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas. Br J Dermatol. 2005;152:43-51.
Link to abstract on PubMed - 18.
- Epstein EH. Basal cell carcinomas: attack of the hedgehog. Nat Rev Cancer. 2008;8:743-754.
Link to abstract on PubMed - 19.
- Rubin LL, de Sauvage FJ. Targeting the hedgehog pathway in cancer. Nat Rev Drug Discov. 2006;5:1026-1033.
Link to abstract on PubMed - 20.
- Williams JA. Hedgehog signaling pathway as a target for therapeutic intervention in basal cell carcinoma. Drug News Perspect. 2003;16:657-662.
Link to abstract on PubMed - 21.
- Polkinghorn WR, Tarbell NJ. Medulloblastoma: tumorigenesis, current clinical paradigm, and efforts to improve risk stratification. Nat Clin Pract Oncol. 2007;4:295-304.
Link to abstract on PubMed - 22.
- Marino S. Medulloblastoma: developmental mechanisms out of control. Trends Mol Med. 2005;11:17-22.
Link to abstract on PubMed - 23.
- Taylor MD, Liu L, Raffel C, et al. Mutations in SUFU predispose to medulloblastoma. Nat Genet. 2002;31:306-310.
Link to abstract on PubMed - 24.
- Zurawel RH, Allen C, Chiappa S, et al. Analysis of PTCH/SMO/SHH pathway genes in medulloblastoma. Genes Chromosomes Cancer. 2000;27:44-51.
Link to abstract on PubMed - 25.
- Scott DK, Straughton D, Cole M, Bailey S, Ellison DW, Clifford SC. Identification and analysis of tumor suppressor loci at chromosome 10q23.3-10q25.3 in medulloblastoma. Cell Cycle. 2006;5:2381-2389.
Link to abstract on PubMed - 26.
- Thompson MC, Fuller C, Hogg TL, et al. Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations. J Clin Oncol. 2006;24:1924-1931.
Link to abstract on PubMed