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Hedgehog pathway signaling is dysregulated in cancer...

What if we could cut the signals?

Learn more about the Hedgehog pathway and its role in cancer

1. Hedgehog pathway 

The Hedgehog pathway plays a key role in cell differentiation and organ formation during embryonic development.

2. Smoothened 

Is a protein receptor located on the cell surface.

3. Gli 

The Gli family of proteins enter the nucleus and are responsible for the transcription of genes.

1 Hedgehog Pathway 2 Smoothened 3 Gli