Research HDIs
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What makes HER2 different?
HER2: a key receptor for dimerization
HER2 is a key receptor for dimerization. HER2 is the only receptor that exists in an "open" conformation, ready to dimerize with other HER family members. Because HER2 is continually ready to dimerize, the overexpression of HER2 promotes the excessive formation of HER2 dimers.3
Preclinical studies also show that HER2-containing dimers have increased signaling potency relative to those without HER2.2