Initiating treatment

• Factors such as significant disease-related symptoms, bulky disease, and lymphocyte and platelet counts are important in determining when to initiate treatment¹²
• Disease stage and the presence of progressive disease also are important factors in deciding when to initiate therapy
  • For patients with asymptomatic early-stage disease (Rai stage I or II, Binet stage A or B), a watch-and-wait approach has been suggested^11,12,27
  • Initiation of treatment is recommended for patients with symptomatic, advanced, or progressive disease,²⁷ and intermediate- and high-risk disease⁹

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