Staging CLL

• The major staging systems used for the classification of CLL are the Rai and Binet staging systems, whose criteria are shown in Table 2¹
• These systems have assisted clinicians in categorizing patients by prognosis, and have provided guidance on designing therapeutic strategies¹
• Survival within each disease stage may vary significantly, particularly in patients with Rai stage 0 and Binet stage A
• The median survival of patients with Rai stage 0 disease is approximately 12 years. Patients with Rai stages II through IV have median survival rates of 5 to 8 years¹⁶ (Table 2 and Figure 2)

Table 2. Rai and Binet staging systems for classification of CLL.^1,9-11,17,18

Figure 2. Overall survival of patients with CLL staged according to the Rai system.¹⁰

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