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Related Resources for this page:
- Future Directions
- Antibody-Drug Conjugates
- Apoptosis
- Bispecific Monoclonal Antibodies
- Glycoengineered Antibodies
- Non-Antibody Biologics
- Targeted Small Molecules
- Apoptosis
- Apoptotic pathways
- The Bcl-2 family
- Apoptosis
- Emerging therapeutic options
- Emerging therapeutic options
- Resisting apoptosis
- Gastric Cancer
- HER1/EGFR as a therapeutic target
- MAPK Signaling
- MEK Inhibitor (GDC-0973)
- Emerging therapeutic options
- PI3K Inhibitor (GDC-0941)
- Reactivating apoptosis
- PI3K/Akt/mTOR Signaling
- Therapeutic potential of HER pathways
- Traditional Monoclonal Antibodies
- B-cell Surface Proteins
- Glossary
- Direct cell death
- Emerging therapeutic options
- Emerging therapeutic options
- The evolving CLL treatment landscape
- Gastric Cancer
- HER Signaling
- HER1/EGFR as a therapeutic target
- HER2:HER3 dimer
- HER2 as a therapeutic target
- HER3 as a therapeutic target
- Emerging therapeutic options
- Obinutuzumab (GA101)
- Therapeutic potential of HER pathways
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Programmed cell death, oncogenesis, and targeting the cell death pathways
- Programmed cell death, or apoptosis, is a normal cellular function and is important in many processes, including embryonic development and the maintenance of appropriate sizes of cell populations1-3
- Apoptosis is also a means for the destruction of cells that are damaged. When a damaged cell no longer has the ability to undergo self destruction, but retains the ability to proliferate, this may result in oncogenesis1,4
- The mechanism of apoptosis is complex and involves several cascading molecular events4
- There are 2 main apoptotic pathways: the extrinsic (involving death receptors) and the intrinsic (involving the mitochondria)5
- Recent research has shown that there may be considerable cross-talk between these 2 pathways6
- For more information on apoptosis, refer to www.ResearchApoptosis.com