Cellular characteristics associated with the development of cancer cells

• When a cell undergoes malignant transformation, it goes through important cellular changes. These hallmarks of cancer are shown in Figure 1
• The hallmarks of cancer that are most relevant to hematology include evading apoptosis, self-sufficiency of growth signals, and insensitivity to antigrowth signals

This figure was adapted with permission from Cell, Vol 100, Hanahan and Weinberg, The Hallmarks of Cancer, pp 57-70, Copyright Elsevier (2000)¹.

Figure 1. Acquired functional capabilities of cancer cells.

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