Targeting apoptosis intracellularly
Therapeutic strategies are also being developed that target apoptosis through the intrinsic pathway. Small-molecule–based antagonists of Bcl-2 family proteins or the IAPs promote apoptosis intracellularly.35 Inhibition of Bcl-2 family proteins and the IAP family may restore the ability of the intrinsic apoptotic pathway to respond to apoptotic stimuli. There is a small-molecule inhibitor targeted to anti-apoptotic Bcl-2 family proteins while SMAC/DIABLO mimetics block IAPs and may sensitize cancer cells to apoptosis (Figure 3.3).35
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Figure 3.3. Small-molecule inhibitors target the intrinsic apoptotic pathway.