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Resisting apoptosis

Normal cells tightly control apoptosis in order to maintain homeostasis.1 Resisting apoptosis is one of the hallmarks of cancer and allows for uncontrolled proliferation and the formation of a tumor.1,2

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The Bcl-2 family

The Bcl-2 superfamily is made up of both pro-apoptotic and anti-apoptotic proteins that are involved in apoptosis.2 Two important anti-apoptotic proteins, Bcl-2 and Bcl-XL, inhibit cellular apoptosis and are overexpressed in many cancers.3

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Reactivating apoptosis

Restoring the cell's ability to respond to apoptotic stimuli may combat tumorigenesis.3 Inhibiting anti-apoptotic proteins like Bcl-2 and Bcl-XL may lead to advances in cancer therapy.1

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Resisting apoptosis

Normal cells tightly control apoptosis in order to maintain homeostasis1. Resisting apoptosis is one of the hallmarks of cancer and allows for uncontrolled proliferation and the formation of a tumor.1,2

Learn more about resisting apoptosis

The Bcl-2 family

The Bcl-2 superfamily is made up of both pro-apoptotic and anti-apoptotic proteins that are involved in apoptosis.2 Two key anti-apoptotic proteins, Bcl-2 and Bcl-XL, inhibit cellular apoptosis and are overexpressed in many cancers.3

Learn more about the Bcl-2 family

Reactivating apoptosis

Restoring the cell's ability to respond to apoptotic stimuli may combat tumorigenesis.3 Inhibiting anti-apoptotic proteins like Bcl-2 and Bcl-XL may lead to advances in cancer therapy.1

Learn more about reactivating apoptosis

Genentech is dedicated to researching the potential benefits of inhibiting apoptosis and its role in advancing cancer therapy.

ResearchApoptosis is a central source for medical professionals, students, and basic and translational researchers to learn more about the importance of apoptosis and its relationship to cancer.

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