What if you could reprogram cell death?
Normal cells tightly control apoptosis in order to maintain homeostasis1. Resisting apoptosis is one of the hallmarks of cancer and allows for uncontrolled proliferation and the formation of a tumor.1,2
The Bcl-2 family
The Bcl-2 superfamily is made up of both pro-apoptotic and anti-apoptotic proteins that are involved in apoptosis.2 Two key anti-apoptotic proteins, Bcl-2 and Bcl-XL, inhibit cellular apoptosis and are overexpressed in many cancers.3
Restoring the cell's ability to respond to apoptotic stimuli may combat tumorigenesis.3 Inhibiting anti-apoptotic proteins like Bcl-2 and Bcl-XL may lead to advances in cancer therapy.1
Genentech is dedicated to researching the potential benefits of inhibiting apoptosis and its role in advancing cancer therapy.
ResearchApoptosis is a central source for medical professionals, students, and basic and translational researchers to learn more about the importance of apoptosis and its relationship to cancer.