Biological Pathways
Dedicated to Rigorous and Groundbreaking Science
As a result of our commitment to basic research, Genentech, a member of the Roche Group, has a robust product pipeline, with innovative compounds designed to target cancer through specific molecular processes.
Select any of the research areas below to learn more:
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Angiogenic Signaling
Angiogenesis is a vital process that facilitates tumor growth and survival. Learn more about key signaling and components that promote tumor angiogenesis.
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Apoptosis
Apoptosis is vital for cellular homeostasis. Learn more about how dysregulation of this critical process leads to tumor growth.
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B-cell Surface Proteins
Learn more about major B-cell surface proteins that are implicated in a multitude of hematologic malignancies.
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HER Signaling
Explore the HER pathways and their role in cancer biology.
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MAPK Signaling
MAPK signaling plays a vital role in cell growth and proliferation. Learn more about the consequences of dysregulated MAPK signaling in cancer cells.
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MET Signaling
Learn more about the mechanism of Met signaling and its effects on tumor cell proliferation, adhesion/motility/invasion, and survival.
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PI3K/Akt/mTOR Signaling
Learn more about various molecular components of the PI3K signaling cascade that promote tumor cell growth and survival.
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Receptor-Mediated Endocytosis
See how this form of cellular internalization can deliver extracellular molecules directly to target cells.