Biological Pathways

Dedicated to Rigorous and Groundbreaking Science

As a result of our commitment to basic research, Genentech, a member of the Roche Group, has a robust product pipeline, with innovative compounds designed to target cancer through specific molecular processes.

Select any of the research areas below to learn more:

  • Angiogenic Signaling

    Angiogenesis is a vital process that facilitates tumor growth and survival. Learn more about key signaling and components that promote tumor angiogenesis.

  • Apoptosis

    Apoptosis is vital for cellular homeostasis. Learn more about how dysregulation of this critical process leads to tumor growth.

  • B-cell Surface Proteins

    Learn more about major B-cell surface proteins that are implicated in a multitude of hematologic malignancies.

  • HER Signaling

    Explore the HER pathways and their role in cancer biology.

  • MAPK Signaling

    MAPK signaling plays a vital role in cell growth and proliferation. Learn more about the consequences of dysregulated MAPK signaling in cancer cells.

  • MET Signaling

    Learn more about the mechanism of Met signaling and its effects on tumor cell proliferation, adhesion/motility/invasion, and survival.

  • PI3K/Akt/mTOR Signaling

    Learn more about various molecular components of the PI3K signaling cascade that promote tumor cell growth and survival.

  • Receptor-Mediated Endocytosis

    See how this form of cellular internalization can deliver extracellular molecules directly to target cells.